Does genetic variation in the D-desaturase promoter modify the association between a-linolenic acid and the prevalence of metabolic syndrome?
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چکیده
Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of a-linolenic acid (ALA), the metabolic precursor of EPA and DHA, has not been studied. The D-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the D-desaturase gene (FADS2) may affect this
منابع مشابه
Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome?
BACKGROUND Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of alpha-linolenic acid (ALA), the metabolic precursor of EPA and DHA, has not been studied. The Delta(6)-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the Delta(6)-desaturase gene (FADS2) may affect this conv...
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Stearoyl-CoA desaturase 1 (SCD1) activity, a key regulator of lipid metabolism, may be associated with the development of metabolic syndrome (MetS). We examined the association of genetic variation in the SCD1 gene with the occurrence of MetS and its five components in a population of Costa Rican adults (n = 2152; mean age, 58 y; range, 18-86 y). Associations of tag single nucleotide polymorphi...
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Abstract Background: Limited observational studies have investigated the association between dietary PUFAs and the metabolic syndrome. The aim of this study was to examine the association between the dietary ω-3 fatty acids including α-linolenic acid (ALA), Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) and ω-6 PUFAs, the interaction and ratio of these dietary PUFAs and the metabol...
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Background: The prevalence of non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries. Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and l...
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